Joint health support

Mangoselect® is composed of xanthones from mangosteen extracts proven to alleviate joint discomfort associated with the body’s natural inflammatory response within 5 days. Supported with 1 clinical trial. 600mg/day.  

To preserve the mobility of both aging populations and active subjects keeping joints active and healthy is a challenge.

Repetitive strenuous exercise injuries and overuse causes: 

Mangoselect® is clinically proven to provide acute benefits on joint discomfort within a few days, to maintain daily routine. 

Characterization of the active compounds

Mangoselect® is a combination of 2 types of xanthones, alpha- and gamma-mangostin, from mangosteen extract. Mangosteen is a tropical fruit used for centuries in traditional Asian medicine. Xanthones, specific polyphenols of mangosteen, are well-described in the literature and recognized for their antioxidant and anti-inflammatory potencies1,2.
Active Compounds

Xanthones: 
    α-mangostin    ≥ 10%
    γ-mangostin    ≥ 1% 

BOTANICAL SOURCES

Mangosteen extract 

Garcinia mangostana L. 

FORMULATION

Recommended daily dosage: 600mg

Science supporting Mangoselect®

PRE-CLINICAL STUDY
PILOT CLINICAL STUDY

Mechanism of action

Mangoselect® contributes to an acute relief in joint discomfort by an action on the mediator of oxidative stress and inflammation.

A mechanistic study confirmed the mode of action of Mangoselect® with a blood measure of a primary inflammatory mediator, TNF-α (tumor necrosis factor alpha), after systemic inflammation peritoneally induced with LPS (lipopolysaccharides) injections. 

TNF-α is significantly reduced in the Mangoselect® group when measured 90 minutes after the injection of LPS.

Clinical study

Single-blind, randomized controlled study.3
Location

University of Pavia, Italia

DURATION
Acute study – 5 days
POPULATION

24 subjects
9 elders
15 athletes

INTAKES

CAPSULES 
2 x 300 mg/day 

PRIMARY OUTCOME
Score on a discomfort rating visual analogue scale (VAS)

Results on joint discomfort

Mangoselect® has been demonstrated effective in significantly reducing joint discomfort for every supplemented subject in both groups within 5 days:

  • Chronic condition (elderlies): discomfort is significantly reduced by 50%.
  • Acute condition (athletes): discomfort is significantly reduced by 31%.
KEY OUTCOMES
  • Clinically proven effective in a 5-day supplementation
  • Acute joint discomfort relief
  • Effective on both athlete’s population with occasional discomfort  and elders with chronical joint discomfort

Applications

Commercial name
Mangoselect®
COMPOSITION
Mangosteen extract
ACTIVE COMPOUNDS

α- mangostin  ≥ 10%
γ- mangostin  ≥ 1%

RECOMMENDED DOSAGE
600 mg/day
APPLICATIONS
Dietary supplements
OTHERS
No allergen, non-GMO, halal, gluten-free

References
1 – Kondo M., et al. 2009; J. Agric. Food Chem.; 57(19):8788-92
2 – Chen L. G., et al, 2008; Food Chem. Tox.; 46(2):688-93
3 – Romain C. & Cases J.; 2015; Agro Food Industry Hi Tech; 26(3):8-13

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Disclaimer

This website is intended to provide information about Fytexia’s ingredients, used in various dietary supplement products around the world. It is intended to provide information to food supplement professionals and is not designed for the general public. As Fytexia’s ingredients are being marketed in a large number of countries, it is the responsibility of each of our customers to ensure that the use of the ingredient and any claim made in the labeling or advertising of the ingredient comply with the applicable rules and regulations.